منابع مشابه
Sodium-dependent norepinephrine-induced currents in norepinephrine-transporter-transfected HEK-293 cells blocked by cocaine and antidepressants.
Transport of norepinephrine (NE+) by cocaine- and antidepressant-sensitive transporters in presynaptic terminals is predicted to involve the cotransport of Na+ and Cl-, resulting in a net movement of charge per transport cycle. To explore the relationship between catecholamine transport and ion permeation through the NE transporter, we established a human norepinephrine transporter (hNET) cell ...
متن کاملImmunomodulation Mechanism of Antidepressants: Interactions between Serotonin/Norepinephrine Balance and Th1/Th2 Balance
Neurotransmitters and hormones regulate major immune functions, including the selection of T helper (Th)1 or Th2 cytokine responses, related to cell-mediated and humoral immunity, respectively. A role of imbalance and dynamic switching of Th1/Th2 system has been proposed, with relative displacement of the immune reserve in relation to complex interaction between Th1/Th2 and neuro-hormonal balan...
متن کاملMolecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters.
Inhibitors of the serotonin transporter (SERT) and norepinephrine transporter (NET) are widely used in the treatment of major depressive disorder. Although SERT/NET selectivity is a key determinant for the therapeutic properties of these drugs, the molecular determinants defining SERT/NET selectivity are poorly understood. In this study, the structural basis for selectivity of the SERT selectiv...
متن کاملThe effects of antidepressants on the retention and metabolism of [3H]-norepinephrine in rat brain slices.
Tricylic antidepressants acutely decrease the neuronal retention of C3H]-norepinehrine (C3H]-NE) by blocking neuronal membrane uptake and/or vesicular uptake and binding. To distinguish between effects upon the plasma membrane and upon the vesicular membrane, the retention, deamination. and O-methylation of [jH]-NE by rat brain slices were investigated in the presence of several antidepressant ...
متن کاملCo-ingestion of tricyclic antidepressants with selective norepinephrine reuptake inhibitors: Overdose in the emergency department.
Case description An 18-year-old female student presents to the emergency department (ED) with a decreased level of consciousness. She was last seen awake the night before, and her parents could not rouse her from sleep that morning. She has a known history of depression, which is treated with an oral 100-mg dose of desvenlafaxine daily and an oral 100-mg dose of amitriptyline once daily at bedt...
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ژورنال
عنوان ژورنال: Science
سال: 2004
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.304.5677.1569c